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Sibutril 15mg is used in combination with a reduced calorie diet and exercise to help people who are overweight lose weight and maintain their weight loss. Sibutramine HCL Monohydrate is in a class of medications called appetite suppressants. It works by acting on appetite control centers in the brain to decrease appetite because of its impact on the neurotransmitter serotonin.When we eat, our bodies release serotonin in the brain.This is why we feel content after eating a large meal.Experts believe that this feeling of happiness we get from food is a survival mechanism: our bodies reward us for succeeding to get food so we are more likely to eat and survive.Of course, this “rewards system” is not really necessary in a world where we just grab food from a supermarket instead of trekking miles to hunt and gather.